Genome-Wide Methylation Landscape Identifies Drivers of Early Carcinogenesis

Authors

  • Eleanor Whitfield Cancer Epigenetics Lab, Cambridge Author
  • Hiroshi Sato Genome Institute, Kyoto Author

Keywords:

carcinogenesis, DNA methylation, epigenetics, genomics, CRISPR screening, precision medicine, targeted therapy, drug resistance, clonal evolution, tumour heterogeneity, prognostic biomarker, p53, BRCA1

Abstract

Aberrant DNA methylation is an early hallmark of malignant transformation. We profiled the genome-wide methylation landscape of 480 pre-malignant and tumour tissues.

We identified 42 differentially methylated regions that distinguish early carcinogenesis from normal epithelium, nominating epigenetic drivers as candidate biomarkers for early detection.

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Genome-Wide Methylation Landscape Identifies Drivers of Early Carcinogenesis

Published

2026-06-04

Issue

Vol. 24 No. 6 (2026)

Section

Research Articles