Mechanisms of Apoptosis Evasion in Treatment-Resistant Carcinoma

Authors

  • Carlos Mendez Cell Death Laboratory, Barcelona Author

Keywords:

apoptosis, treatment resistance, carcinogenesis, oncology, histone modification, mutational signature, copy-number variation, microsatellite instability, immune checkpoint, liquid biopsy, circulating tumour DNA, p53, BRCA1

Abstract

Evasion of apoptosis is a core hallmark of cancer and a driver of therapy resistance. We dissected apoptotic priming in matched pre- and post-treatment carcinoma samples.

Resistant tumours upregulated anti-apoptotic BCL-2 family members; BH3-mimetic priming restored sensitivity, suggesting a route to re-sensitise resistant carcinoma.

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Mechanisms of Apoptosis Evasion in Treatment-Resistant Carcinoma

Published

2026-06-12

Issue

Vol. 24 No. 6 (2026)

Section

Research Articles