Single-Cell Genomics Reveals Clonal Evolution in Colorectal Tumours

Authors

  • Aisha Rahman Tumour Genomics Unit, UCL Author

Keywords:

genomics, clonal evolution, tumour heterogeneity, carcinogenesis, prognostic biomarker, cancer genomics, epigenomics, transcriptomics, DNA repair, somatic mutation, immunotherapy, p53, BRCA1

Abstract

Intratumoural heterogeneity shapes treatment response. We applied single-cell DNA and RNA sequencing to 36 colorectal tumours spanning disease stages.

Reconstructed phylogenies revealed early fixation of driver mutations followed by branched subclonal evolution, with metastasis-seeding clones detectable in primary tumours.

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Single-Cell Genomics Reveals Clonal Evolution in Colorectal Tumours

Published

2026-06-06

Issue

Vol. 24 No. 6 (2026)

Section

Research Articles