Targeting Drug-Tolerant Persister Cells in Lung Adenocarcinoma

Authors

  • Marcus Bennett Thoracic Oncology, MD Anderson Author

Keywords:

carcinogenesis, drug tolerance, persister cells, oncology, drug resistance, clonal evolution, tumour heterogeneity, prognostic biomarker, cancer genomics, epigenomics, transcriptomics, tumour suppressor, oncogene

Abstract

A subpopulation of drug-tolerant persister cells underlies relapse after targeted therapy. We characterised persister states in lung adenocarcinoma using lineage tracing.

Persister cells adopted a reversible, epigenetically defined state dependent on lipid peroxidase activity, revealing a therapeutic vulnerability to combination treatment.

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Targeting Drug-Tolerant Persister Cells in Lung Adenocarcinoma

Published

2026-06-05

Issue

Vol. 24 No. 6 (2026)

Section

Research Articles