Telomere Dysfunction Drives Chromosomal Instability in Aggressive Carcinomas

Authors

  • Yuki Tanaka Division of Cancer Genomics, Osaka Author
  • Laura Esposito Institute of Molecular Oncology, Milan Author

Keywords:

carcinogenesis, oncology, biomarkers, genomics, chromosomal instability, circulating tumour DNA, whole-genome sequencing, RNA sequencing, single-cell sequencing, CRISPR screening, precision medicine, targeted therapy, p53, BRCA1

Abstract

Telomere attrition precipitates a state of chromosomal instability that fuels tumour heterogeneity. We characterised telomere dynamics across 312 aggressive carcinomas using whole-genome sequencing.

Telomere crisis signatures correlated with copy-number complexity and poor prognosis, nominating telomere maintenance as a targetable axis in oncology.

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Telomere Dysfunction Drives Chromosomal Instability in Aggressive Carcinomas

Published

2026-06-07

Issue

Vol. 24 No. 6 (2026)

Section

Research Articles