Current Issue
Vol. 12 No. 3 (2026)
Published August 3, 2026
Original Research
Early identification of treatment responders could transform diabetes care. We measured a panel of 24 serum biomarkers in 612 patients initiating second-line therapy and modelled 12-month glycaemic response. A four-marker...
The tumour microenvironment shapes colorectal cancer progression. We performed quantitative histopathology on 340 resection specimens, scoring immune infiltration, stromal content, and vascular density. High peritumoural...
Synovial inflammation in rheumatoid arthritis is clinically heterogeneous. We applied single-cell RNA sequencing to synovial tissue from 28 patients spanning early and established disease. We identified two distinct...
Polygenic risk scores promise to refine cardiovascular risk stratification but are largely derived from European populations. We evaluated a recalibrated score in a multi-ethnic cohort of 41,000 participants. The score...
The durability of early rhythm control benefit in atrial fibrillation remains uncertain. We followed 5,200 patients for a median of seven years in a prospective registry. Early rhythm control was associated with a sustained...
Chronic neuroinflammation is implicated in cognitive ageing. We tracked plasma inflammatory markers and cognition in 1,800 older adults over eight years. Elevated baseline neuroinflammatory markers predicted accelerated...
